T-cell receptor V beta expression in normal human skin.
نویسندگان
چکیده
منابع مشابه
oligoclonal expression of t-cell receptor beta variable genes in normal human endometrium
in spite of their key role in various immunological processes occurring in the endometrium, t cells- especially + subtype- residing in this mucosal tissue, have not been extensively explored. we present here the profile of expressed genes for variable region of chain of t cell receptor (tcr) in normal endometrium as compared to peripheral blood. samples from endometrium were taken from norm...
متن کاملHuman T cell receptor V beta gene polymorphism
Southern blot hybridizations with human T cell receptor V beta gene probes were used to determine the sizes of the various V beta gene subfamilies. An analysis of DNA samples from 100 unrelated individuals identified a single individual who lacked one V beta gene segment. A second individual had an apparently different repertoire of V beta gene segments in one subfamily, as assayed by hybridiza...
متن کاملOligoclonal expression of T-cell receptor Beta variable genes in normal human endometrium.
In spite of their key role in various immunological processes occurring in the endometrium, T cells- especially ab+ subtype- residing in this mucosal tissue, have not been extensively explored. We present here the profile of expressed genes for variable region of b chain of T cell receptor (TCR) in normal endometrium as compared to peripheral blood. Samples from endometrium were taken from norm...
متن کاملT cell receptor V beta expression in human intestine: regional variation in postnatal intestine and biased usage in fetal gut.
A panel of T cell receptor V beta specific monoclonal antibodies was used to analyse V beta gene usage at different sites in human postnatal and fetal intestine. In normal small intestine, at a single site, different patients showed expansion of T cells expressing individual V beta s. Lamina propria and epithelial T cells from the same patient showed overlapping but not identical V beta dominan...
متن کاملExpression of T-cell receptor V beta regions in granular lymphocyte-proliferative disorders.
In a recent issue of Blood, de Totero et all reported the preferential T-cell receptor (TCR) V region usage in the expansion of CD8' granular lymphocytes (GL). They found that both monoclonal and polyclonal CD8+TCRa@+ GL shared the Vp5.3 region, as shown by their positivity for LC4 monoclonal antibody (MoAb), and suggested a preferential Vp gene segment usage in the rearrangement process of CD8...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1993
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.90.4.1267